In 2005, Tariq et al. conducted a study to compare the effects of Eperisone, a muscle relaxant, with physiotherapy on stroke patients. The goal was to determine whether Eperisone could effectively reduce muscle stiffness, known as spasticity, similar to the effects of physiotherapy.

The study included 26 stroke patients, ranging from 15 to 75 years old, who participated in a three-week trial at the Department of Physiotherapy, PIMS. The participants were randomly assigned to two groups: one group received Eperisone treatment, while the other underwent formal physiotherapy. The primary outcome measure was the change in the grade of muscle tone, and the safety and tolerability of Eperisone were also assessed.

The results showed that both Eperisone and physiotherapy had comparable effects in reducing spasticity and improving muscle tone in stroke patients. Among those who received Eperisone treatment, noticeable improvements in muscle tone grades were observed. For example, some patients saw a shift from a higher grade of spasticity to a lower one.

In terms of safety, a few adverse events were reported among the patients who received Eperisone, such as vomiting, fatigue, headache, dry mouth, and epigastric pain. However, overall, the patients tolerated the treatment well.

These findings suggest that Eperisone could be a potential alternative or complementary treatment option for spasticity in stroke patients. It showed effectiveness in improving muscle tone, similar to physiotherapy. This could be particularly valuable when physiotherapy is not readily accessible or feasible for patients. However, further research is needed to confirm and expand upon these results, including larger studies with longer durations and additional outcome measures.

It’s important to note that this study had some limitations, such as its small sample size and short treatment period. A larger-scale study with a more diverse population and longer follow-up would provide stronger evidence. Additionally, exploring the combined effects of Eperisone and physiotherapy could optimize spasticity management.

Overall, this study sheds light on the potential of Eperisone as a treatment option for spasticity in stroke patients. While more research is needed, these findings offer hope for improving the quality of life for stroke survivors dealing with muscle stiffness.

Reference: Mohammad, T., Nasim, A., Mohammad, A., Sohail, R., Mazhar, B., & Mohammad, I. (2005). Eperisone compared to Physiotherapy on muscular tone of stroke patiehts: a prospective randomized open study.